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Fig. 3 | Virology Journal

Fig. 3

From: Unraveling the genetic variations underlying virulence disparities among SARS-CoV-2 strains across global regions: insights from Pakistan

Fig. 3

Protein structural analysis of Mac-1 specific amino acid substitutions within Nsp3 of SARS-CoV-2 from Pakistani Isolates. Comparison of 3-dimensional conformations of SARS-CoV-2 macrodomain-1 with their corresponding mutant versions. (a) Wild-type structure of Mac-1 (PDB entry: 6W02). (b-d) Superimposed structure of wild-type (PDB entry: 6W02) and mutant versions of Mac-1 (M265I: EPI_ISL_1406395, G307C: QQH15880, and L357I: QQL13872). Descriptions of color codes are given in the panel. Deviated residues in terms of backbone torsion angles (Φ°, Ψ°) are shown in red color. Structural deviations are examined by RMSD values and given in the panel b, c, and d. Note. Primary sequence and secondary structural level details for comparisons in a–d are given in Additional File 1: Tables S5

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Virology Journal

ISSN: 1743-422X