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Table 1 Characteristics of HIV-positive participants and metabolite levels when participants stratified according to specific amino acids variants

From: A pilot investigation of the association between HIV-1 Vpr amino acid sequence diversity and the tryptophan-kynurenine pathway as a potential mechanism for neurocognitive impairment

 

Position 22 (n = 29)

P value

Position 41 (n = 27)

P value

Position 45 (n = 30)

P value

Position 55 (n = 28)

P value

Amino acid

I

L

 

G

N

S

 

Y

H

 

A

T

 

N (%)

16 (55%)

13 (45%)

-

15 (55%)

6 (22%)

6 (22%)

-

18 (60%)

12 (40%)

-

7 (25%)

21 (75%)

-

Age in years, mean (SD)

47.31 (6.23)

49.08 (8.43)

0.523

47.47 (4.9)

46.83 (7.6)

45.7 (8.7)

0.822/ 0.548

48.44 (6.5)

48.1 (8.4)

0.895

49.43 (6.6)

47.57 (6.6)

0.525

Sex, female N (%)

10 (63%)

11 (85%)

0.624

10 (67%)

5 (83.3%)

4 (6707%)

0.733

15 (83%)

9 (75%)

0.576

7 (64%)

27 (84%)

0.145

CD4 +, mean (SD)

274.50 (119.21)

313.71 (139.52)

0.662

272.2 (191)

213.7 (74.2)

367 (222.6)

0.564/ 0.513

287.71 (164.3)

241. 8 (125.4)

0.535

150.5 (72.8)

330.92 (152)

0.132

Body Mass index (BMI)

235.5 (16)

223 (34)

0.532

22.3 (3.4)

23 (8.4)

21.5 (2.5)

0.747/

0.640

23 (4.8)

23.5 (5.8)

0.811

20.5 (4)

24.2 (5.4)

0.118

Smoker

9 (56%)

7 (64%)

0.701

7 (47%)

3 (50%)

6 (100%)

0.167

9 (56%)

8 (67%)

0.576

6 (86%)

11 (55%)

0.148

Alcohol use

9 (56%)

5 (45%)

0.581

6 (40%)

2 (33%)

5 (83%)

0.253

7 (44%)

6 (50%)

0.743

3 (42%)

11 (55%)

0.580

Locality, rural N (%)

6 (38%)

9 (69%)

0.089

10 (67%)

4 (67%)

3 (50%)

0.757

10 (56%)

7 (58%)

0.880

4 (57%)

11 (52%)

0.827

Trp, ug/mL

0.16 (0.06)

0.13 (0.07)

0.223

0.17 (0.07)

0.13 (0.08)

0.13 (0.04)

0.303/ 0.226

0.15 (0.07)

0.15 (0.06)

0.710

0.15 (0.07)

0.15 (0.06)

0.822

Kyn, ug/mL

0.0087 (0.003)

0.0088 (0.003)

0.904

0.01 (0.002)

0.01 (0.003)

0.008 (0.004)

0.587/ 0.254

0.009 (0.002)

0.009 (0.001)

0.646

0.009 (0.003)

0.008 (0.003)

0.589

Kyn/Trp ratio

0.062 (0.027)

0.085 (0.042)

0.106

0.07 (0.034)

0.089 (0.045)

0.0586 (0.032)

0.290/ 0.418

0.068 (0.036)

0.071 (0.032)

0.739

0.074 (0.038)

0.061 (0.026)

0.375

QUIN, ug/mL

0.0013 (0.0009)

0.0015 (0.0009)

0.543

0.0017 (0.0009)

0.0013 (0.0004)

0.0009 (0.0007)

0.368/.073

0.0016 (0.0009)

0.0012 (0.0007)

0.157

0.002 (0.0012)

0.001 (0.0005)

0.022

KA, ug/mL

0.000014 (00002)

0.00002 (0.00003)

0.115

0.00003 (0.00003)

0.000008 (0.00003)

0.000007 (0.00003)

0.076/ 0.126

0.00002 (0.00003)

0.00001 (0.00001)

0.725

0.00001 (0.00001)

0.00002 (0.00003)

0.666

  1. Data represented as mean (SD) or N (%). Logarithmically transformed variables has been back transformed for presentation purposes. At position 41, we compared G vs. N and G vs. S indicated by p-value/p-value, respectively. Data were unavailable for 2 participants in the L22 and Y45 groups and 1 participant in the T55 group (alcohol use and smoking)
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Virology Journal

ISSN: 1743-422X