Table 3 Analysis results of NF-κB, toll like receptor and TNF signal pathway
Channel name | Time period (h) | Adjust upwards and downwards | Gene |
|---|---|---|---|
NF-κB signal pathway | 24 | ↑ | MIP-1β, IL-8 and IkBα |
|  | ↓ | BTK, CARD11, PRCKB, PLCG2, BLNK, CD14, TLR4 and TNFSF11 | |
36 | ↑ | MIP-1β, IkBα, VACM-1, MD-2 | |
|  | ↓ | COX2 | |
48 | ↓ | TNFAIP3 and COX2 | |
Toll like receptor signaling pathway | 24 | ↑ | IL-8, MIP-1β, CCL26 and IkBα |
|  | ↓ | BTK, TLR2, TLR4, TLR5, CD14, TLR7/8, AP1 and CD80 | |
36 | ↓ | PI3K, TLR4, TRAF3, OPN, CD86, IkBα, MIP-1β, IL-6, RANTES and MD-2 | |
48 | ↑ | IKBKE | |
|  | ↓ | MIP-1β | |
TNF signaling pathway | 24 | ↑ | CCL20, Mmp3, Mmp9, CCL26, VEGFD, IL18R1, MLKL and IkBα |
36 | ↑ | CX3CL1, Mmp3, VCAM1, CD86 and IkBα | |
|  | ↓ | LIF, SOCS3, EDN1 and PTGS1 | |
48 | ↓ | CREB5, CCL26, LIF, TNFAIP3, MMP9 and PTGS2 |