Fig. 2
From: Mechanisms and consequences of mRNA destabilization during viral infections
IAV Cap-Snatching and PA-X. (1) IAV particles package eight vRNPs that each include a segment of the viral RNA bound to nuceloproteins (NPs) and the viral RdRp. These vRNPs are imported into the nucleus B where they interact with RNA PolII to snatch the caps off of nascent host mRNA transcripts. C The endonuclease PA-X arises from a ribosomal frameshift in the PA gene. D PA-X preferentially cleaves the GCUG motif and the resulting mRNA fragments are further digested by exonucleases