Fig. 1
From: Mechanisms and consequences of mRNA destabilization during viral infections
Herpesviruses host shutoff. A alpha-herpesviruses package the ribonuclease Vhs in their tegument, and it is released into the cytoplasm after viral entry. B Vhs cleaves the host mRNA. The exonuclease Xrn1 further degrades the cleavage fragments. C During late lytic infection, the viral proteins VP16, VP22, and ICP27 bind to and inhibit Vhs from degrading mRNAs. D Gamma-herpesviruses encode the SOX endonuclease, cleaves host mRNAs at an early stage of mRNA translation