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Fig. 5 | Virology Journal

Fig. 5

From: HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors

Fig. 5

Molecular docking of reverse transcriptase inhibitors to HIV-1 and HTLV-1 reverse transcriptase. A Molecular surface diagram of HIV-1 reverse transcriptase with nucleoside reverse transcriptase inhibitor (NRTIs) binding site (active site) highlighted purple (left). Interaction plots of indicated NRTIs in the active site in their most energetically favourable conformation (1 of 10) (right). B Molecular surface diagram HTLV-1 reverse transcriptase with nucleoside reverse transcriptase inhibitor (NRTIs) binding site (active site) highlighted purple (left). Interaction plots of indicated NRTIs in the active site in their most energetically favourable conformation (1 of 10) (right). C Data summary of molecular docking testing 10 different conformations in either the HIV-1 reverse transcriptase or HTLV-1 reverse transcriptase. Related to Additional file 1: Fig. S2

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Virology Journal

ISSN: 1743-422X