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Fig. 2 | Virology Journal

Fig. 2

From: HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors

Fig. 2

Rationalisation for theoretical model for HTLV-1 reverse transcriptase and molecular docking of reverse transcriptase inhibitors. A Cartoon representation of predicted HTLV-1 reverse transcriptase Alphafold2 model, and B its molecular surface. The predicted binding site of non-nucleoside reverse transcriptase inhibitors (NNRTIs) (allosteric site) and the binding site of nucleoside reverse transcriptase inhibitors (NRTIs) (active site) have been highlighted in purple. Amino acid sequence alignment for the active sites of HTLV-1 (NCIB: NC_001436), MMLV (PDBID:4MH8), HIV-1 (PDBID:1JLA), and HERV (PDBID:7SR6). Highlighted in purple are the amino acids defined for MMLV, HIV-1, and HERV (and predicted for HTLV-1) to interact with NNRTIs (above) and with NRTIs (below). Related to Additional file 1: Fig. S1

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Virology Journal

ISSN: 1743-422X