Unraveling the dynamic mechanisms of natural killer cells in viral infections: insights and implications

Table 4 Several PID disorders with altered NK cell function and subsequent viral infection susceptibility

Disease	Gene mutation	NK cell alteration	Viral Infection susceptibility	References
X-linked and Autosomal recessive severe combined immunodeficiency (SCID)	IL2RG/JAK3	Absent or low NK cells	Multiple infections	[150, 151]
CD25 deficiency	IL2RA	Low NK cell number	CMV	[152]
NEMO deficiency	IKBKG	Low NK cell function	CMV	[153]
IKK2 deficiency	IKBKB	Low NK cell number	CMV	[154]
CTLA4 deficiency	CTLA4	Low NK cell function	CMV and EBV	[155]
Chediak-Higashi syndrome	LYST	Low NK cell function	EBV	[156]
X-linked lymphoproliferative syndrome type 1	SH2D1A	Low NK cell function	EBV	[157]
X-linked lymphoproliferative syndrome type 2	XIAP	Low NK cell number and function	EBV	[158]
Non-X-linked lymphoproliferative syndrome	ITK	Low NK cell number and function	EBV	[159]
Familial hemophagocytic lymphohistiocytosis 2/3/4/5	PRF1/UNC13D/STX11/STXBP2	Low NK cell function	Herpesviruses	[160,161,162,163]
Hermansky-Pudliak syndrome type 2/9	AP3BP1/BLOC1S6	Low NK cell function	Herpesviruses	[164, 165]
Wiskott-Aldrich syndrome	WAS	Low NK cell function	Herpesviruses	[166]
WIPF1 deficiency	WIPF1	Low NK cell function	Herpesviruses	[167]
RASGRP1 deficiency	RASGRP1	Low NK cell function	Herpesviruses	[168]
DOCK8 immunodeficiency syndrome	DOCK8	Low NK cell function	HPV	[169]
RLTPR deficiency	CARMIL2/RLTPR	Low NK cell function	HPV	[170]
X-linked hyper IgM	CD40LG	Low NK cell function	Enteroviruses	[171]

ISSN: 1743-422X