Table 3 Human NK cell deficiencies and subsequent viral infection susceptibility

cNKD

GATA2

Normal or low NK cell number + decreased NK cell lytic function + absent or severe reduction in CD56^bright

VZV, HSV, CMV, HPV

[137, 145, 146]

MCM4

low NK cell number + diminished CD56^dim subset + higher prevalence of the CD56^bright subset

EBV, recurrent respiratory infections

[138, 147]

MCM10

low NK cell number + higher prevalence of the CD56^bright subset

fatal vulnerability to CMV

[139]

GINS1

low NK cell number + diminished CD56^dim subset + higher prevalence of the CD56 ^bright subset

CMV

[142]

GINS4

Reduction of NK cell number and function + severe Neutropenia

CMV, varicella, recurrent herpes simplex labialis and et al

[143]

IRF8

low NK cell number and function + declined CD56^dim subset + higher prevalence of the CD56^bright subset

EBV

[140]

RTEL1

severely reduced NK cell number and function

VZV

[141, 148]

fNKD

FCGR3A

Normal NK cell numbers + diminished NK cell function

EBV, HSV, HPV

[149]