Table 1 Comparison between CD56dim NK Cells and CD56bright NK Cells
Feature | CD56dim NK Cells | CD56bright NK Cells |
|---|---|---|
CD56 expression | Low | High |
CD16 expression | High | Low/negative |
ADCC | High | Low |
Cytotoxicity | More cytotoxic | Less cytotoxic |
Cytokine production | Lower cytokine production | Higher cytokine production |
Surface marker expression | High KIR, and low to negative CD94/NKG2A | Low to negative KIR and high CD94/NKG2A |
CD117 (c-Kit) | Negative | Positive |
CCR7 | Negative | Positive |
CXCR3 | High | Low to negative |
CXCR1/CX3CR1 | Positive | Negative |
L-selectin (CD62L) | Low to negative | High |
NKp46 | Lower | Higher |
Localization | Predominantly peripheral tissues | Predominantly secondary lymphoid tissues |
Developmental stage | More mature | Less mature |
Proliferation rate in response to IL-2 | Low | High |