Recent advances in various adeno-associated viruses (AAVs) as gene therapy agents in hepatocellular carcinoma

Table 1 The inception of prominent AAV isolates within clinical applications of liver-specific GT, encompassing their receptor affinities and tissue selectivity

Serotype	Origin	Receptor and co-receptors	Tissue tropism	References
AAV2	Human	HSPG, integrin αVβ5 and α5β1, HGFR, LamR, FGFR1, CD9, AAVR	Liver, SM, CNS, Kidney, Retina Heart, Lungs	[45, 70,71,72]
AAV3	Human	HSPG, LamR, FGFR1, HGFR, AAVR	Liver, HCC, SM, cochlear inner hair cells	[45, 70,71,72,73]
AAV6	Human	α2,3/ α2,6 N-linked SA, EGFR, HSPG, AAVR	Liver, SM, Heart, Airway, Retina	[45, 70, 71]
AAV8	NHP	LamR, AAVR	Liver, Retina, SM, CNS, Pancreas, Kidney, Heart	[45, 70, 71]
AAV9	Human	N-linked galactose, LamR, AAVR	Liver, Heart, SM, Pancreas, CNS, Retina, Lung,	[45, 70, 71]

ISSN: 1743-422X