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Fig. 5 | Virology Journal

Fig. 5

From: Preclinical assessment of an anti-HTLV-1 heterologous DNA/MVA vaccine protocol expressing a multiepitope HBZ protein

Fig. 5

Recruitment of T CD8+ lymphocytes and cytokine production in mice immunized with the recombinant DNA-MVA. A Representative graphs of the gating strategy used in the flow cytometry assays. The A3 peptide and PMA / Ionomycin were used as positive controls. B–B1 Graph of the total percentage of CD8+ T lymphocytes, double-positives for INF-γ and TNF-α recruited after restimulation. Statistical differences were observed between the groups DNA-MVA vs MVA (wt). B2 Graph of the total percentage of T CD8+ lymphocytes producers of TNF-α and IL-2 recruited after restimulation with HBZ peptides. Legend (symbols): Circle: Cells from mice immunized with the recombinant DNA-MVA regimen; Square: Cells from mice inoculated only with the MVA (wt) vector; Triangle: Cells from mice inoculated only with the Addavax adjuvant. N = 7

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Virology Journal

ISSN: 1743-422X