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Fig. 4 | Virology Journal

Fig. 4

From: Phillyrin ameliorates influenza a virus-induced pulmonary inflammation by antagonizing CXCR2 and inhibiting NLRP3 inflammasome activation

Fig. 4

The cytokine-cytokine receptor interaction is responsible for the suppressive effect of phillyrin on IAV-induced pneumonia. (a) Hierarchical cluster analysis of DEGs among CON group, virus group and phillyrin group. Red and blue hues indicate upregulated and downregulated expression, respectively. (b) The quantity of DEGs in virus-vs.-CON and phillyrin-vs.-virus groups, and comparison of DEGs between virus-vs.-CON and phillyrin-vs.-virus. (c) KEGG enrichment bubble diagram with common DEGs. The mRNA expression of CXCR2 (d), CCR2 (e), CCR1 (f), CCR5 (g). Mean ± SD (n = 6/group). One-way ANOVA, # p < 0.05 vs. CON, * p < 0.05 vs. IAV.

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Virology Journal

ISSN: 1743-422X