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Table 1 The cytotoxicity, anti-RABV effect, and selectivity indices of the tested compounds

From: Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro

Compounds

CC50(μM)

IC50(μM)

SI(CC50/IC50)

CDDO-Me

0.71 (0.553–0.867)

0.0445 (0.0414–0.0476)

9.59

CDDO

0.78 (0.505–1.055)

0.0620 (0.0467–0.0773)

8.13

Ribavirin

 > 50

29.36 (27.21–31.51)

 > 1.70

T-705

 > 2000

367.50 (360.64–374.36)

 > 5.44

  1. CC50: 50% cytotoxic concentration; IC50: 50% inhibitory concentration; SI: selectivity index; CDDO-Me: bardoxolone methyl; CDDO: bardoxolone; T-705: favipiravir