Fig. 3
From: Bardoxolone methyl inhibits the infection of rabies virus via Nrf2 pathway activation in vitro
Confirmation of the inhibitory effects of CDDO-Me, ribavirin, and T-705. A N2a cells were infected with CVS-11 at an MOI of 10 and treated with different doses of CDDO-Me (0.5 μM), ribavirin (50 μM), or T-705 (1000 μM) for 24 h. Virus-infected cells that were treated with DMSO served as a control in the experiment. The culture supernatants were harvested, and the viral particles were detected by a direct fluorescent antibody (DFA) assay; apple-green fluorescence represents fluorescein isothiocyanate (FITC)-labeled RABV, and the scale bar represents 100 μm. B Culture supernatants were sampled, and the viral titers of the culture supernatants were measured. The data shown represent the mean and standard deviation from two independent experiments that were performed in triplicate. The mean and standard deviation are shown. Statistical analysis was carried out using one-way ANOVA with Dunnett's post hoc test (*p < 0.05, **p < 0.01, ***p < 0.001″)