Table 2 Log Hazard ratios obtained for the drugs tested, along with standard deviations (SDs), FDR-adjusted p-values, and Lymphocyte proliferation values (see Methods) along with FDR-adjusted p-values. The two last columns indicate the drugs used in the machine learning drug repurposing prediction study and the significance of the prediction
Drugbank ID | Drug | N | LHR estimate | LHR SD | LHR CI 5% | LHR CI 95% | LHR p-value | LHR FDR p-value | Lymphocyte counr | LC CI 5% | LC CI 95% | LC p-value | LC FDR p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DB09258 | Bemiparin | 1347 | -1.48449 | 0.16861 | -1.81495 | -1.15402 | < 0.00001 | < 0.00001 | 6.19153 | 0.00990 | 0.01908 | < 0.00001 | < 0.00001 |
DB01225 | Enoxaparin | 3237 | -1.20921 | 0.10316 | -1.41141 | -1.00702 | < 0.00001 | < 0.00001 | 11.31073 | 0.01233 | 0.01750 | < 0.00001 | < 0.00001 |
DB01234 | Dexamethasone | 2469 | -0.75679 | 0.10273 | -0.95813 | -0.55545 | < 0.00001 | < 0.00001 | 9.42789 | 0.01233 | 0.01881 | < 0.00001 | < 0.00001 |
DB01050 | Ibuprofen | 519 | -0.65959 | 0.20808 | -1.06743 | -0.25175 | 0.00153 | 0.01095 | 2.18280 | 0.00080 | 0.01503 | 0.02961 | 0.07372 |
DB09038 | Empagliflozin | 239 | -0.42376 | 0.18355 | -0.78352 | -0.06401 | 0.02096 | 0.06730 | 2.26829 | 0.00126 | 0.01714 | 0.02430 | 0.06177 |
DB01120 | Gliclazide | 322 | -0.41723 | 0.15098 | -0.71315 | -0.12131 | 0.00572 | 0.02492 | 2.74039 | 0.00257 | 0.01549 | 0.00649 | 0.02262 |
DB00829 | Diazepam | 641 | -0.41669 | 0.12112 | -0.65408 | -0.17930 | 0.00058 | 0.00473 | 2.16427 | 0.00057 | 0.01141 | 0.03084 | 0.07525 |
DB00146 | Calcifediol | 530 | -0.40717 | 0.15363 | -0.70827 | -0.10607 | 0.00804 | 0.03164 | 3.40110 | 0.00502 | 0.01869 | 0.00073 | 0.00328 |
DB00641 | Simvastatin | 1588 | -0.40558 | 0.07026 | -0.54328 | -0.26789 | < 0.00001 | < 0.00001 | 5.16632 | 0.00523 | 0.01163 | < 0.00001 | 0.00001 |
DB00983 | Formoterol | 1380 | -0.37040 | 0.08596 | -0.53888 | -0.20192 | 0.00002 | 0.00018 | 5.13579 | 0.00650 | 0.01453 | < 0.00001 | 0.00001 |
DB00394 | Beclomethasone dipropionate | 792 | -0.36901 | 0.11319 | -0.59085 | -0.14717 | 0.00111 | 0.00849 | 4.15390 | 0.00594 | 0.01656 | 0.00004 | 0.00045 |
DB00275 | Olmesartan | 413 | -0.36562 | 0.12879 | -0.61803 | -0.11320 | 0.00453 | 0.02209 | 2.37903 | 0.00137 | 0.01416 | 0.01786 | 0.05002 |
DB01261 | Sitagliptin | 448 | -0.36512 | 0.12515 | -0.61040 | -0.11984 | 0.00353 | 0.01956 | 2.56016 | 0.00179 | 0.01355 | 0.01077 | 0.03552 |
DB00635 | Prednisone | 1818 | -0.35982 | 0.08332 | -0.52311 | -0.19652 | 0.00002 | 0.00018 | 5.43363 | 0.00644 | 0.01371 | < 0.00001 | < 0.00001 |
DB00331 | Metformin | 1896 | -0.35648 | 0.06733 | -0.48845 | -0.22451 | < 0.00001 | < 0.00001 | 3.88744 | 0.00273 | 0.00827 | 0.00010 | 0.00073 |
DB00999 | Hydrochlorothiazide | 2197 | -0.35148 | 0.06036 | -0.46979 | -0.23318 | < 0.00001 | < 0.00001 | 3.98046 | 0.00273 | 0.00802 | 0.00007 | 0.00067 |
DB00126 | Ascorbic acid | 840 | -0.33321 | 0.10674 | -0.54241 | -0.12400 | 0.00180 | 0.01219 | 3.66682 | 0.00406 | 0.01344 | 0.00026 | 0.00127 |
DB01373 | Calcium | 641 | -0.30728 | 0.10895 | -0.52082 | -0.09375 | 0.00480 | 0.02250 | 3.75161 | 0.00479 | 0.01529 | 0.00019 | 0.00103 |
DB00128 | Aspartic acid | 648 | -0.29845 | 0.13140 | -0.55598 | -0.04091 | 0.02313 | 0.06911 | 3.66511 | 0.00543 | 0.01791 | 0.00027 | 0.00127 |
DB00318 | Codeine | 1019 | -0.29747 | 0.09647 | -0.48655 | -0.10840 | 0.00204 | 0.01247 | 3.92417 | 0.00441 | 0.01324 | 0.00009 | 0.00073 |
DB00169 | Cholecalciferol | 725 | -0.28067 | 0.10502 | -0.48651 | -0.07483 | 0.00753 | 0.03062 | 3.66953 | 0.00437 | 0.01440 | 0.00026 | 0.00127 |
DB00316 | Acetaminophen | 7258 | -0.27573 | 0.04035 | -0.35481 | -0.19665 | < 0.00001 | < 0.00001 | 6.53570 | 0.00361 | 0.00671 | < 0.00001 | < 0.00001 |
DB00178 | Ramipril | 509 | -0.26557 | 0.11700 | -0.49489 | -0.03624 | 0.02323 | 0.06911 | 2.29420 | 0.00102 | 0.01294 | 0.02222 | 0.06025 |
DB01222 | Budesonide | 1047 | -0.25260 | 0.08800 | -0.42508 | -0.08012 | 0.00410 | 0.02174 | 3.28003 | 0.00289 | 0.01151 | 0.00108 | 0.00460 |
DB08906 | Fluticasone furoate | 662 | -0.20888 | 0.10361 | -0.41196 | -0.00580 | 0.04381 | 0.11921 | 4.00962 | 0.00547 | 0.01595 | 0.00007 | 0.00067 |
DB00338 | Omeprazole | 5173 | -0.20373 | 0.04349 | -0.28897 | -0.11848 | < 0.00001 | 0.00004 | 3.92296 | 0.00189 | 0.00566 | 0.00009 | 0.00073 |
DB00584 | Enalapril | 1598 | -0.19957 | 0.06725 | -0.33138 | -0.06775 | 0.00300 | 0.01745 | 3.76049 | 0.00297 | 0.00945 | 0.00018 | 0.00103 |
DB00193 | Tramadol | 949 | -0.16897 | 0.08313 | -0.33191 | -0.00604 | 0.04209 | 0.11921 | 3.16350 | 0.00252 | 0.01072 | 0.00162 | 0.00636 |
DB00207 | Azithromycin | 2465 | -0.16216 | 0.05779 | -0.27542 | -0.04889 | 0.00502 | 0.02267 | 4.36750 | 0.00338 | 0.00888 | 0.00001 | 0.00018 |
DB00695 | Furosemide | 1920 | 0.24131 | 0.05212 | 0.13916 | 0.34346 | < 0.00001 | 0.00005 | -3.74328 | -0.00805 | -0.00251 | 0.00019 | 0.00103 |