Table 1 The ROS-mediated cellular events and related main adverse effects in severe RSV infection
The ROS-mediated cellular events | The main adverse effects |
|---|---|
NLRP3 inflammasome activation | Excessive innate immune responses and lung inflammatory injury |
NET release | Airway obstruction, mucus hypersecretion, and heightened lung damage |
HMGB1 release | Increased viral load, augmented type 2 inflammation, and airway remodeling |
DNA damage | Excessive innate immune responses, cell senescence, and airway tissue remodeling |
Acquired ciliopathies | Barrier dysfunctions and reduced mucociliary clearance |