Fig. 2
From: The potential use of bacteria and bacterial derivatives as drug delivery systems for viral infection
Schematic of localization of several molecules in BGs. Several techniques for antigen presentation in the BG envelope complex—BG themselves transport native antigens, such as lipopolysaccharide (LPS), outer membrane protein (OMP), inner membrane protein (IMP), toxin coregulated pilus (TCP), flagella, pili—target antigen (TA) may be presented on the cell surface through fusion with OmpA—the PPS can be encapsulated with target antigen via maltose binding protein (MBP)-SbsA- FPs, through fusion of the target antigen with MBPor as sole target antigen utilizing the gene III signal sequence. Protein target antigen may be combined into the inner membrane through E′, L′ or E′/L′-anchoring, biotinylated antigen can be bound to E′-FXa-StrpA membrane anchors, DNA carrying the lac operator site can be bound to L′-anchored lacI suppressor molecules—target antigen attached with SbsA-/SbsB proteins develop S-layers in the PPS [59]