Table 3 Meta-analysis of the effect of HBV on the risk of maternal outcomes based on continents, age, and gestational diabetes
Variables | Categories | No. study | Pooled RR (% 95 CI) | Heterogenity Assesment between sudies | Heterogenity Assesment between subgroup | Publication bias assesments | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
I2 (%) | P value | Q | Q | Pvalue | B | SE | P value | ||||
PreEclampsia | |||||||||||
 Overall pooled estimate | 20 | 1.10 (1.04–1.16) | 92.06 | 0.00 | 239.28 | – | – | − 0.94 | 0.661 | 0.156 | |
 Continent | Europe | 2 | 0.71 (0.55–0.92) | 0.00 | 0.89 | 0.02 | 53.44 | 0.00 | |||
Asia | 15 | 1.24 (1.17–1.32) | 92.14 | 0.00 | 178.05 | ||||||
American | 3 | 0.80 (0.72–0.90) | 74.28 | 0.02 | 7.78 | ||||||
 Age |  < 30 | 7 | 1.21 (1.10–1.34) | 43.54 | 0.10 | 10.63 | 19.45 | 0.00 | |||
 > 30 | 4 | 0.82 (0.72–0.95) | 11.69 | 0.33 | 3.40 | ||||||
 Gestational age |  < 38 | 2 | 0.91 (0.75–1.12) | 0.00 | 0.67 | 0.18 | 2.57 | 0.11 | |||
 > 38 | 8 | 1.09 (1.00–1.20) | 80.20 | 0.00 | 35.35 | ||||||
GDM | |||||||||||
 Overall pooled estimate | 29 | 1.16 (1.13–1.18) | 92.89 | 0.00 | 393.94 | – | – | − 0.89 | 0.979 | 0.361 | |
 Continent | Europe | 1 | 2.24 (1.76–2.85) | – | – | – | 108.08 | 0.00 | |||
Asia | 24 | 1.11 (1.09–1.14) | 91.58 | 0.00 | 273.13 | ||||||
American | 4 | 1.54 (1.44–1.65) | 76.44 | 0.01 | 12.73 | ||||||
 Age |  < 30 | 13 | 1.12 (1.08–1.16) | 94.80 | 0.00 | 249.95 | 1.29 | 0.26 | |||
 > 30 | 7 | 1.16 (1.11–1.21) | 86.03 | 0.00 | 35.79 | ||||||
 Gestational age |  < 38 | 3 | 1.38 (1.24–1.54) | 65.84 | 0.05 | 5.85 | 14.62 | 0.00 | |||
 > 38 | 11 | 1.11 (1.07–1.14) | 85.62 | 0.00 | 69.53 | ||||||
Preterm birth | |||||||||||
 Overall pooled estimate | 27 | 1.17 (1.14–1.20) | 94.32 | 0.00 | 457.57 | – | – | − 0.72 | 0.883 | 0.417 | |
 Continent | Europe | 2 | 1.27 (1.09–1.48) | 0.00 | 0.76 | 0.09 | 125.25 | 0.00 | |||
Asia | 20 | 1.07 (1.04–1.10) | 85.47 | 0.00 | 130.79 | ||||||
American | 5 | 1.48 (1.41–1.55) | 98.01 | 0.00 | 201.43 | ||||||
 Age |  < 30 | 12 | 1.02 (0.97–1.06) | 79.03 | 0.00 | 52.46 | 0.02 | 0.90 | |||
 > 30 | 6 | 1.02 (0.96–1.09) | 85.73 | 0.00 | 35.03 | ||||||
 Gestational age |  < 38 | 3 | 1.30 (1.17–1.45) | 0.00 | 0.52 | 1.33 | 27.62 | 0.00 | |||
 > 38 | 8 | 0.95 (0.91–1.00) | 74.05 | 0.00 | 26.97 | ||||||
Eclampsia | |||||||||||
 Overall pooled estimate | 3 | 1.48 (0.95–2.29) | 0.00 | 0.87 | 0.28 | – | – | − 0.58 | 1.749 | 0.7387 | |
Gestationalhypertension | |||||||||||
 Overall pooled estimate | 15 | 0.83 (0.77–0.90) | 12.78 | 0.31 | 16.05 | – | – | 0.00 | 0.604 | 0.997 | |
Eclampsia + PreEclampsia | |||||||||||
 Overall pooled estimate | 4 | 0.85 (0.82–0.89) | 48.41 | 0.12 | 5.82 | – | – | 1.60 | 0.700 | 0.0220 | |
Abortion | |||||||||||
 Overall pooled estimate | 2 | 0.97 (0.71–1.33) | 78.96 | 0.03 | 4.75 | – | – | – | – | – | |
Neonatal death | |||||||||||
 Overall pooled estimate | 6 | 0.83 (0.67–1.03) | 0.00 | 0.95 | 1.18 | – | – | 0.22 | 0.711 | 0.755 | |