Fig. 6

LKB1 is involved in the activation of AMPK by NS1. A Conformation of the NS1-LKB1 complex. NS1 protein is shown in blue and AMPK1 protein is shown in green. a is the overall binding mode of the complex, b is the protein–protein interaction amino acid residues, and c is the 2D map of residue interactions. B Effect of NS1 and its structural domain on LKB1 expression. C LKB1 knockdown attenuates the effect of NS1-induced autophagy. * represents comparison with MOCK, *p < 0.05, **p < 0.01, ***p < 0.001; # represents comparison with DENV-2 NS1-OE + LKB1-KD group, #p < 0.05, ##p < 0.01, ##p < 0.001; △ represents comparison with DENV-2 NS1-mut + LKB1-KD group, △p < 0.05, △△p < 0.01, △△△p < 0.001