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Fig. 4 | Virology Journal

Fig. 4

From: DENV-2 NS1 promotes AMPK-LKB1 interaction to activate AMPK/ERK/mTOR signaling pathway to induce autophagy

Fig. 4

The DENV-2 NS1 Wing domain plays a key role in the interaction of NS1 with AMPK. A Westernblots detection of changes in related molecules upon deletion of different structural domains of NS1. * represents comparison with MOCK, *p < 0.05, **p < 0.01, ***p < 0.001; # represents comparison with DENV-2 NS1-OE group, #p < 0.05, ##p < 0.01, ##p < 0.001. B Co-ip. C The fusion proteins DENV-2 NS1-Wing domain with GST tag, GST-only and AMPK with HA tag were subjected to GST pulldown assay in vitro, respectively

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Virology Journal

ISSN: 1743-422X