Fig. 1

A comparison of viral variants prior to and after the therapy. A Heat map displaying representative viral families from sixteen pools. The names of the columns at the bottom of the graph represent pool numbers. (The data has been standardized.) The red bar at the top of the graph represents blood samples collected prior to treatment, while the blue bar represents blood samples collected seven days after therapy. The row labels on the graph’s right side correspond to the names of viral gates. The reads are log-transformed with log2 as the base, and the figure legend is located in the upper right corner. B Alpha diversity between the two groups (Shannon index). The horizontal bars within boxes indicate the medians. The 75th and 25th percentiles are shown by the top and bottom boxes, respectively. The top and lower whiskers extend to data within 1.5 the interquartile range of the box’s upper and lower edges, respectively. The Days are denoted by their respective colors (see color legend). C Principal coordinates (PCoA) analysis. Based on the Bray–Curtis ecological distance matrix, the PCoA analysis reveals disparities in species composition. D, E Wilcoxon signed-rank test of Siphoviridae and Myoviridae. Red indicates the number of reads prior to therapy, whereas blue indicates the number of reads after seven days of treatment. All analyses with p values 0.05 were statistically significant