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Fig. 1 | Virology Journal

Fig. 1

From: Characterization of intrinsic and effective fitness changes caused by temporarily fixed mutations in the SARS-CoV-2 spike E484 epitope and identification of an epistatic precondition for the evolution of E484A in variant Omicron

Fig. 1

Epidemic dynamics of spike E484 variants. (A) Number of sequences with the indicated S:484 mutation deposited in GISAID per day (January 2020 to April 2022). (B) Effect of E484A, E484Q, and E484K mutations on spike protein surface charge. Left panel shows the SARS-CoV-2 spike protein (green), Protein Data Bank accession number 6LZG bound to ACE2 (grey), with residue 484 highlighted in red. The black dashed square indicates the area enlarged in the polarity display panels on right. Blue indicates positive charge. Red indicates negative charge

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Virology Journal

ISSN: 1743-422X