Fig. 2

Transcriptional activity of HPV 33 LCR variants in HeLa cells. Cells were co-transfected with luciferase reporter plasmids containing full-length HPV 33 LCR sequence variants and pRL-TK Control Vector. Luciferase activities are shown relative to the activity of cells transfected with pGL2-Basic vector. Data are from four independent experiments, with standard errors shown as error bars. Stars indicate the significance of difference in transcriptional activity compared to 33LCRHU01 transfected cells according to ratio t-test (*p < 0.05, ***p < 0.001). The variant lineages comprising the tested variants are indicated under the bars