Table 1 Types of AS have been identified in AdV, HPV, and IAV
From: Virus usurps alternative splicing to clear the decks for infection
Virus | Viral gene | Splice type | Regulator factor | Consequence |
|---|---|---|---|---|
AdV | E1A RNA | Alternative 5’ splice site and alternative 3' splice site | Celluar SR proteins | Generate 9S, 10S, 11S, 12S, and 13S viral mRNA |
|  | L1 RNA | Alternative 3’ splice site | Cellular SR proteins and viral E4-ORF; viral cis-acting elements, 3RE and 3VDE | Generate 52/55 K and IIIa viral mRNA |
HPV | E6/E7 RNA | Alternative 3’ splice site | Cellular hnRNP and SR proteins; viral cis-acting elements SA409 | Generate E6 and E7 mRNA |
IAV | M RNA | Alternative 5’ splice site | Cellular SR proteins, hnRNP protein family and NS1-BP, and viral polymerase complex as well as NS1 | Generate M2 mRNA |
|  | NS RNA | Alternative 5’ splice site | Viral NS1 | Generate NS2 mRNA |