Table 4 Dominant model analyses for ACE2 genetic variants with multiple genotypes. Six variants listed have the multiple altered genotyping that had insignificant statistical association with the severity of COVID-19
ACE2 Single nucleotide variant | Genotype | Severity | P | OR (CI 95%) | FDRb | |
|---|---|---|---|---|---|---|
Serious n = 68 | Non-Serious n = 56 | |||||
rs1391451327 | AA GG + TT | 61 (0.897) 7 (0.103) | 55 (0.982) 1 (0.018) | 0.090 | 0.158 (0.19–1.329) | 0.54 |
rs2285666 | CC AA + TT + CT | 32 (0.47) 36 (0.53) | 29 (0.517) 27 (0.483) | 0.600 | 0.828 (0.408–1.680) | 1.80 |
rs768883316 | TT CC + AA | 64 0.941) 4 (0.059) | 53 (0.946) 3 (0.054) | 0.900 | 0.906 (0.194–4.227) | 1.35 |
rs180878567 | AA TT + GG | 68 (1.00) 0 (0) | 53 (0.946) 3 (0.054) | 0.999 | NA | 1.19 |
rs756597390 | AA CC + TT | 67 (0.985) 1 (0.015) | 55 (0.982) 1 (0.018) | 0.890 | 1.218 (0.074–19.92) | 1.78 |
rs768583671 | AA CC + GG + TT | 65 (0.955) 3 (0.045) | 56 (1.00) 0 (0) | 0.999 | NA | 0.999 |