Table 3 Genetic association study of ACE2 variants with severity of COVID-19. rs2285666 was a commonly altered variant (63 patients) followed by rs139141327 (8 patients). None of the variants had a statistically significant association with the severity of COVID-19 though the variants were found in the serious groups. ^bBenjamini-Hockberg method. CI, confidence Interval; FDR, false discovery rate; NA, does not apply; OR, odds ratio

rs180878567

Reference (AA)

Altered (TT)

Altered (GG)

121 (0.976)

2 (0.016)

1 (0.008)

68 (1.00)

0 (0)

0 (0)

53 (0.946)

2 (0.036)

1 (0.018)

0.999

NA

1.998

rs751227277

Reference (GG)

Altered (TT)

123 (0.992)

1 (0.008)

67 (0.985)

1 (0.015)

56 (1.00)

0 (0)

1.000

NA

1.571

rs1391451327

Reference (AA)

Altered (GG)

Altered (TT)

116 (0.935)

1 (0.008)

7 (0.057)

61 (0.897)

1 (0.015)

6 (0.088)

55 (0.982)

0 (0)

1 (0.018)

0.096

0.538 (0.260–1.116)

2.112

rs1469916451

Reference (TT)

Altered (CC)

122 (0.984)

2 (0.016)

67 (0.985)

1 (0.015)

55 (0.982)

1 (0.018)

0.890

0.906 (0.224–3.664)

2.797

rs1601703288

Reference (TT)

Altered (AA)

121 (0.976)

3 (0.024)

67 (0.985)

1 (0.015)

54 (0.964)

2 (0.036)

0.463

0.739 (0.329–1.659)

5.093

rs201159862

Reference (TT)

Altered (AA)

121 (0.976)

3 (0.024)

67 (0.985)

1 (0.015)

54 (0.964)

2 (0.036)

0.463

0.739 (0.329–1.659)

3.395

rs751170930

Reference (CC)

Altered (GG)

123 (0.992)

1 (0.008)

67 (0.985)

1 (0.015)

56 (1.00)

0 (0)

1.000

NA

1.466

rs756737634

Reference (TT)

Altered (GG)

122 (0.984)

2 (0.016)

67 (0.985)

1 (0.015)

55 (0.982)

1 (0.018)

0.890

0.821 (0.50-13.427)

2.447

rs1927831624

Reference (TT)

Altered (CC)

123 (0.992)

1 (0.008)

67 (0.985)

1 (0.015)

56 (1.00)

0 (0)

1.000

NA

1.375

rs764947941

Reference (AA)

Altered (TT)

123 (0.992)

1 (0.008)

67 (0.985)

1 (0.015)

56 (1.00)

0 (0)

1.000

NA

1.294

rs73195521

Reference (TT)

Altered (GG)

123 (0.992)

1 (0.008)

67 (0.985)

1 (0.015)

56 (1.00)

0 (0)

1.000

NA

1.222

rs752242172

Reference (GG)

Altered (TT)

122 (0.984)

2 (0.016)

67 (0.985)

1 (0.015)

55 (0.982)

1 (0.018)

1.000

NA

1.157

rs781378335

Reference (TT)

Altered (CC)

121 (0.976)

3 (0.024)

68 (1.00)

0 (0)

53 (0.946)

3 (0.054)

0.999

NA

1.831

rs756597390

Reference (AA)

Altered (CC)

Altered (TT)

122 (0.984)

1 (0.008)

1 (0.008)

67 (0.985)

0 (0)

1 (0.015)

55 (0.982)

1 (0.018)

0 (0)

0.622

0.686 (0.154–3.062)

2.736

rs148006212

Reference (TT)

Altered (GG)

123 (0.992)

1 (0.008)

67 (0.985)

1 (0.015)

56 (1.00)

0 (0)

1.000

NA

1.100

rs780478736

Reference (GG)

Altered (AA)

121 (0.976)

3 (0.024)

67 (0.985)

1 (0.015)

54 (0.964)

2 (0.036)

0.463

0.635 (0.189–2.136)

2.546

rs768583671

Reference (AA)

Altered (CC)

Altered (GG)

Altered (TT)

121 (0.976)

1 (0.008)

1 (0.008)

1 (0.008)

65 (0.955)

1 (0.015)

1 (0.015)

1 (0.015)

56 (1.00)

0 (0)

0 (0)

0 (0)

0.999

NA

1.1.690

rs2285666

Reference (CC)

Altered (AA)

Altered (CT)

Altered (TT)

61 (0.492)

1 (0.008)

6 (0.048)

56 (0.452)

32 (0.48)

1 (0.015)

2 (0.029)

33 (0.485)

29 (0.51)

0 (0)

4 (0.07)

23 (0.42)

0.966

0.993 (0.716–1.377)

2.125

rs1569241829

Reference (CC)

Altered (GG)

123 (0.992)

1 (0.008)

67 (0.985)

1 (0.015)

56 (1.00)

0 (0)

1.000

NA

1.047

rs768883316

Reference (TT)

Altered (CC)

Altered (AA)

117 (0.944)

2 (0.016)

5 (0.04)

64 (0.942)

0 (0)

4 (0.058)

53 (0.946)

2 (0.036)

1 (0.018)

0.655

1.140 (0.642–2.023)

2.401

rs560997634

Reference (AA)

Altered (CC)

122 (0.984)

2 (0.016)

67 (0.985)

1 (0.015)

55 (0.982)

1 (0018)

0.890

1.218 (0.074–19.92)

2.175

rs1927830489

Reference (GG)

Altered (TT)

123 (0.992)

1 (0.008)

68 (1.00)

0 (0)

55 (0.0982)

1 (0.018)

1.000

NA

1.00