Angiotensin-converting enzyme 2 (ACE2) polymorphisms and susceptibility of severe SARS-CoV-2 in a subset of Pakistani population

Table 2 Minor allele frequency (MAF) and results of exact test to assess deviations from Hardy-Weinberg equilibrium (HWE)

ACE2	Major Allele	Minor Allele	Class	Consequences	MAF	HWE
rs768883316	T	A	SNP	Intronic Variant	0.055	2.6928E-6
rs560997634	A	C	SNP	Intronic Variant	0.006	1.00
rs201159862	T	A	SNP	Intronic Variant	0.024	0.0206
rs751170930	C	G	Insertion	Splice donor region variant	0.012	0.0206
rs1569241829	C	G	SNP	Splice donor 5th base variant	0.012	0.0206
rs2285666	T	G	SNP	Splice donor region variant	0.497	8.2762E-15
rs756737634	T	G	Indel	Splice donor region variant	0.018	0.0206
rs146991645	T	G	SNP	Synonymous variant	0.018	0.0206
rs1601703288	T	A	SNP	Missense variant	0.018	1.00
rs1391451327	A	T	SNP	Missense variant	0.055	3.5006E-5
rs1927830489	G	T	SNP	Intronic Variant	0.006	1.00
rs1927831624	T	C	SNP	Intronic Variant	0.006	1.00
rs764947941	A	T	SNP	Intronic Variant	0.012	0.0206
rs752242172	G	T	SNP	Intronic Variant	0.006	1.00
rs73195521	G	T	SNP	Intronic Variant	0.006	0.0206
rs781378335	T	C	SNP	Intronic Variant	0.018	0.0206
rs756597390	A	C	SNP	Intronic Variant	0.012	0.0206
rs780478736	G	A	SNP	Intronic Variant	0.345	2.8697E-14
rs148006212	T	G	SNP	Intronic Variant	0.012	0.0206
rs768583671	A	C	Indel	Intronic variant	0.006	1.00

Altered variants had the MAF of < 0.1. Out of all 4 variants were splice donor site, missense, and insertion. rs560997634, rs1601703288 and, rs768583671 were in linkage equilibrium (LE). HWE = 1 considered as variants are in LE

ISSN: 1743-422X