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Table 1 Statistical association of demographic and clinical characteristics with severity of COVID-19: Fever, cough, dyspnea, loss of taste, elevated d-dimer, LDH, and CRP levels were all significantly associated with the severity of the disease. Fever, cough, and dyspnea were commonly present in all severity levels, while loss of taste and smell were more frequently associated with mild and moderate cases

From: Angiotensin-converting enzyme 2 (ACE2) polymorphisms and susceptibility of severe SARS-CoV-2 in a subset of Pakistani population

Characteristics

n = 143

Severity

P valuea

Serious

77 (53.8)

Non-Serious

66 (46.2)

Age (Years)

<=50

> 50

37 (25.9)

106 (74.1)

18 (12.6)

59 (41.3)

19 (13.3)

47 (32.9)

0.566

Gender

Male

Female

80 (55.9)

63 (44.1)

44 (30.8)

33 (23.1)

36 (25.2)

30 (21)

0.866

Ethnicity

Sindhi

Urdu

Punjabi

Pathan

35 (24.5)

82 (57.3)

18 (12.6)

8 (5.6)

15 (10.5)

45 (31.5)

14 (9.8)

3 (2.1)

20 (14)

37 (25.9)

4 (2.8)

5 (3.5)

0.081

Hypertension

Yes

No

83 (58)

60 (42)

46 (32.2)

31 (21.7)

37 (25.9)

29 (20.3)

0.735

Diabetes Mellitus

Yes

No

71 (49.7)

72 (50.3)

42 (29.4)

35 (24.5)

29 (20.3)

37 (25.9)

0.242

Fever

Yes

No

90 (62.9)

53 (37.1)

59 (41.3)

18 (12.6)

31 (21.7)

35 (24.5)

0.001*

Cough

Yes

No

58 (40.6)

85 (59.4)

40 (28)

37 (25.9)

18 (12.6)

48 (33.6)

0.004*

Dyspnea

Yes

No

87 (60.8)

56 (39.2)

64 (44.8)

13 (9.1)

23 (16.1)

43 (30.1)

0.001*

Arthralgia

Yes

No

18 (12.6)

125 (87.4)

9 (6.3)

68 (47.6)

9 (6.3)

57 (39.9)

0.803

Ageusia

Yes

No

4 (2.8)

139 (97.2)

0 (0)

77 (53.8)

4 (2.8)

62 (43.4)

0.043*

Anosmia

Yes

No

6 (4.2)

137 (95.8)

2 (1.4)

75 (52.4)

4 (2.8)

62 (43.3)

0.415

TLC

Raised

Normal

Below Normal

120 (83.9)

21 (14.7)

2 (1.4)

62 (43.3)

15 (10.5)

0 (0)

58 (40.6)

6 (4.2)

2 (1.4)

0.075

De-Dimer

Raised

Normal

105 (73.4)

38 (26.6)

66 (46.2)

11 (7.7)

39 (27.3)

27 (18.9)

< 0.001*

Ferritin

Raised

Normal

100 (69.9)

43 (30.1)

56 (39.2)

21 (14.7)

44 (30.8)

22 (15.4)

0.468

LDH

Raised

Normal

127 (88.8)

16 (11.2)

76 (53.1)

1 (0.7)

51 (35.7)

15 (10.5)

< 0.001*

CRP

Raised

Normal

92 (64.3)

51 (35.7)

62 (43.3)

15 (10.5)

30 (21)

36 (25.2

< 0.001*

Pro-calcitonin

Raised

Normal

139 (97.2)

4 (2.8)

74 (51.7)

1 (0.7)

65 (45.5)

3 (2.1)

0.642

Outcome

Discharged

Deaths

110 (76.9)

33 (23.1)

48 (33.6)

29 (20.3)

62 (43.4)

4 (2.8)

< 0.001*

  1. Categorical data represented as n and frequency in percentages (%), *significant p value (P < 0.05), aChi square test/Fischer’s Exact Test, TLC: Total Leukocyte Count, LDH: Lactate Dehydrogenase, CRP: C-Reactive Protein