Fig. 2

DEPs in HEV-infected cells supplemented with FBS or PS. A Venn diagram. The red circle indicates the DEPs in HEV-infected cells (HEV vs. Mock); the yellow circle indicates the DEPs in HEV-infected cells supplemented with PS (HEV + PS vs. Mock); and blue circles indicate the DEPs in HEV-infected cells supplemented with PS (HEV + PS vs. HEV). B PPI network of 110 dysregulated proteins among 128 DEPs. C Hierarchical clustering analysis of DEPs in cells with or without HEV infection and with PS or FBS supplementation. Clustering with log2(FC) values; red indicates up-regulated proteins, and green indicates down-regulated proteins. D Functional classification of the 128 dysregulated proteins by GO enrichment analysis. E KEGG pathway analysis was performed to investigate the significant pathways wherein the 128 proteins were enriched in accordance with the related networks for pathway mapping