Epstein-Barr virus variation in people living with human immunodeficiency virus in southeastern China

Table 2 The hot mutations of LMP-1 C-ter in patients with HIV and the control group

	HIV-infected patients (n = 80)	HIV-negative participants(n = 52)	P value
LMP1 variant characterization			0.831
China 1	59 (73.75)	37 (71.15)
China 2	17 (21.25)	13 (25.00)
China 3	0 (0)	0 (0)
Med + /Med-	3 (3.75)	2 (3.85)
Alaskan	0 (0)	0 (0)
North Carolina	0 (0)	0 (0)
Unknown	1 (1.25)	0 (0)
LMP1 variant distribution
del30 present	59 (73.75)	37 (71.15)	0.743
Position in B95-8		< 0.001
168,257–168,286	43 (53.75)	0 (0)
168,266–168,295	14 (17.50)	37 (71.75)
168,267–168,296	1 (1.25)	0 (0)
168,242–168,340	1 (1.25)	0 (0)
None	21 (26.25)	15 (28.85)
ins15 present	80 (100)	17 (32.69)	< 0.0001
Position in B95-8
168,400–168,414	80 (100%)	17 (32.69)
None	0 (0)	35 (67.71)
No. of rep33 units			0.675
2.5copies	2 (2.50)	4 (7.69)
3.5copies	19 (23.75)	12 (23.08)
4.5copies	21 (26.25)	12 (23.08)
5.5copies	18 (22.25)	16 (30.77)
6.5copies	13 (16.25)	7 (13.46)
7.5copies	4 (5.00)	1 (1.92)
8.5copies	2 (2.50)	0 (0)
9.5copies	1 (1.25)	0 (0)

Data was are median (IQR) or n (%); LMP-1: latent membrane protein 1, C-ter: carboxy terminus, HIV: human immunodeficiency virus, del30: 30-bp deletion, ins15: 15-bp insertion, rep33:33-bp tandem repeats

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