Table 3 Comparative analysis of inflammatory cytokines between Omicron variants ∆872 BA.2 and WT BA.2 breakthrough infected adult patients
Variables (median [IQR]) | Normal reference range | BA.2.2 Infected adult Patients (n = 40) | ∆872 BA.2.3 Infected adult Patients (n = 7) | p-value |
|---|---|---|---|---|
CRP (μg/mL) | 0–8.2 | 1.815(0.43–3.81) | 2.95(1.26–4.51) | 0.309 |
IL-2 (pg/mL) |  ≤ 11.4 | 0.74(0.49–1.23) | 1.23(0.79–2.06) | 0.057 |
IL-4 (pg/mL) |  ≤ 12.9 | 1.93(1.57–2.42) | 2.39(1.49–3.01) | 0.212 |
IL-6 (pg/mL) |  ≤ 20.0 | 3.83(3.13–7.02) | 4.72(4.08–8.56) | 0.135 |
IL-10 (pg/mL) |  ≤ 5.9 | 1.9(1.45–2.45) | 3.18(1.94–3.89) | 0.021 |
TNF-α (pg/mL) |  ≤ 5.5 | 1.83(1.38–2.15) | 2.07(1.83–2.75) | 0.054 |
IFN-γ(pg/mL) |  ≤ 17.3 | 4.31(2.28–6.18) | 2.22(1.73–2.86) | 0.035 |
IL17A (pg/mL) |  ≤ 20.6 | 2.07(1.71–2.78) | 3.52(2.0–4.31) | 0.031 |
IL1-β (pg/mL) |  ≤ 12.1 | 1.09(0.77–2.05) | 1.52(1.15–1.91) | 0.306 |
IL-5 (pg/mL) |  ≤ 3.4 | 0.68(0.48–0.89) | 0.73(0.49–0.97) | 0.614 |
IL12P70 (pg/mL) |  ≤ 3.2 | 1.63(1.40–2.17) | 1.86(1.11–2.01) | 0.710 |
IFN-α (pg/mL) |  ≤ 7.9 | 2.20(1.22–5.725) | 3.67(1.62–18.11) | 0.169 |
IL-8 (pg/mL) |  ≤ 21.4 | 3.92(2.73–12.49) | 10.26(7.18–29.53) | 0.039 |