Table 2 Presumed VP7 neutralizing antigen epitope differences between N4006 and strains used in vaccines or G9 strains circulating globally

N4006

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

E6398/2019/CHN/G9-E2 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

Fuzhou19-58/2019/CHN/G9-E1 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

JZ1810/2018/CHN/G9 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

Km15119/2016/CHN/G9 ^a

T

T

G

T

E

W

K

N

Q

D

T

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

Km15100/2015/CHN/G9 ^a

T

T

G

T

E

W

K

N

Q

D

T

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

SC8/2014/CHN/G9 ^a

T

T

G

A

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

SC6/2013/CHN/G9 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

BJ-Q794/2012/CHN/G9 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

BJ-Q532/2011/CHN/G9 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

Tokyo18-43/2018/JPN/G9-E2 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

NS17-A959/2017/RUS/G9 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

3,000,053,718/2015/USA/G9 ^a

T

T

G

T

E

W

K

N

Q

D

T

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

3,000,014,466/2014/USA/G9 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

1CR24/2015/THA/G9 ^a

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

Fuzhou19-84/2019/CHN/G9-E1 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

G

G

Fuzhou18-152/2018/CHN/G9-E2 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

G

G

BJ-Q33/2010/CHN//G9 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

G

G

LL09131481/2009/CHN/G9P8-E1 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

L169/2000–2006/CHN/G9 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

CAU10-55/2010/KOR/G9 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

G

G

SP014/2013/JPN/G9 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

3468/2016/KEN/G9 ^b

T

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

3,000,558,285/2016/USA/G9P8 ^b

A

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

ITA/JES11/2010/G9P8 ^b

T

T

G

T

E

W

K

N

Q

D

A

I

D

K

Q

N

T

A

D

N

K

D

S

T

L

S

E

S

G

Rotasiil-AU32/G9 ^c

A

T

G

T

E

W

K

D

Q

D

A

I

D

K

Q

N

T

A

D

T

K

D

S

T

L

S

E

S

G

Rotavac-116E/G9 ^c

I

T

G

T

E

W

K

G

Q

D

A

I

D

K

Q

N

T

A

D

N

K

N

S

T

L

S

E

N

G

RV1/G1 ^d

T

T

N

G

E

W

K

D

Q

S

V

V

D

K

Q

N

V

D

N

T

K

D

Q

N

L

S

M

N

G

Rotavin-M1/G1 ^d

T

T

S

G

E

W

K

D

Q

N

V

V

D

R

Q

N

V

D

N

T

K

D

Q

N

L

S

T

N

G

RV5/G1 ^d

T

T

N

G

D

W

K

D

Q

S

V

V

D

K

Q

N

V

D

N

T

K

D

Q

S

L

S

M

N

G

RV5/G2 ^d

A

N

S

D

E

W

E

N

Q

D

T

M

N

K

Q

D

V

S

N

S

R

D

N

T

S

D

I

S

G

RV5/G3 ^d

T

T

N

N

S

W

K

D

Q

D

A

V

D

K

Q

D

A

N

K

D

K

D

A

T

L

S

E

A

G

RV5/G4 ^d

S

T

S

T

E

W

K

D

Q

N

L

I

D

K

Q

D

T

A

D

T

R

A

S

G

E

S

T

S

G

LLR/G10 ^d

T

T

N

N

E

W

T

S

Q

N

A

V

D

K

Q

N

T

G

D

T

R

N

S

S

L

S

E

A

G