Fig. 4

VP8^* presumed surface exposure antigen epitope amino acid residue variations between N4006 and the RV1, RV5, and ROTAVIN-M1 vaccine viruses. Top left corner, mesh diagram of RVA VP4; the VP8^* domain (PDB 4V7Q) is boxed [27]. The front (upper right corner) and back (lower right corner) of the enlarged VP8^* domain are shown, with the surface-exposed antigen epitopes 8 − 1 (red), 8 − 2 (orange), 8 − 3 (magenta), and 8 − 4 (green) (PDB 1KQR) [29]. VP8^* surface-exposed antigen epitope amino acid variations between N4006 and the RV1, RV5, and ROTAVIN-M1 vaccine viruses are shown. Amino acid residues in N4006 that differed from both vaccines are in blue, and residues that differed from one of the vaccines are in yellow