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Fig. 3 | Virology Journal

Fig. 3

From: Ultrastructural study confirms the formation of single and heterotypic syncytial cells in bronchoalveolar fluids of COVID-19 patients

Fig. 3

Syncytial cells formed by multiple origins of cells of COVID-19-induced ARDS patients. (A) PAP imaging of monocyte and neutrophil origin with multilobed and horseshoe shape nucleus. (B) Multilobed nuclei and centric nuclein confirm the neutrophil and monocyte cells, respectively, with a moderate level of SARS-CoV-2 infection in IF. (C-F) Membrane fusion between monocytes and two adjacent neutrophils under TEM imaging with different magnifications. Monocyte was identified due to the presence of active lipid bodies and a central nucleus. The neutrophilic granules and phagocytes confirm the neutrophil origin of the adjacent cells. N, nucleus; M, mitochondria; RB, residual body; L, lipid body; white arrow, SARS-CoV-2 virus; black arrowhead, the fusion site of the plasma membrane.

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Virology Journal

ISSN: 1743-422X