Table 1 Characteristics of the included studies and diagnostic test performance of procalcitonin (PCT) for coinfections
Study | Country | No. of patients | Male/female | Median age (IQR) | Cut-off (μg/L) | AUC | TP | FP | FN | TN | SEN (%) | SPE (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alberto Dolci 2021 | Italy | 83 | 68/15 | 64 (53.3–72.0) | 0.80 | 0.67 | 20 | 14 | 13 | 36 | 0.61 | 0.72 | 0.59 | 0.73 |
Charlotte Vanhomwegen 2021 | Belgium | 66 | 41/25 | 61 (49–71) | 0.50 | 0.68 | 5 | 34 | 2 | 25 | 0.71 | 0.42 | 0.13 | 0.93 |
Emma J. Kooistra 2021 | The Netherlands | 84 | 58/26 | NA | 0.50 | NA | 10 | 8 | 28 | 38 | 0.26 | 0.83 | 0.56 | 0.58 |
Isabell Pink 2021 | Germany | 99 | 72/27 | 57 (18–91) | 0.55 | 0.88 | 29 | 13 | 3 | 54 | 0.91 | 0.81 | 0.69 | 0.95 |
Michael May 2021 | USA | 2443 | 1395/1048 | NA | 0.50 | NA | 63 | 653 | 85 | 1642 | 0.43 | 0.72 | 0.09 | 0.95 |