Fig. 3
From: MHC class I links with severe pathogenicity in C57BL/6N mice infected with SARS-CoV-2/BMA8
The effect of H-2Kbon pathogenicity of BMA8 strain in C57BL/6N mice. (A) The lungs of different groups of mice were sampled and photographed, the gray arrows indicated mild bleeding, and the black arrow indicated severe tissue disease. (B) The viral RNA copies and viral titers were detected in lungs and turbinates of different groups. (C) The expression of vNP in lung tissues of BMA8-infected mice with or without H-2Kb mAbs treatment; β-actin was used as a loading control. (D) H&E staining was performed on the lung tissues of mice, showing representative photos of different groups. (E) The pathology scores were summarized according to Fig. 2B. (F) IHC analysis of NP expression in lung tissues. (G) The percentage of NP-positive cells was summarized according to IHC staining in (F). *p < 0.05, **p < 0.01, ***p < 0.001, ns means no statistical difference