Evaluation of the clinical efficacy of vaginal treatment options for persistent high-risk human papillomavirus infection after excisional treatment of cervical high-grade squamous intraepithelial lesions: a systematic review and Bayesian network meta-analysis

Tang, Yiqian; Tong, Qing; Dai, Ning; Xu, Cai

doi:10.1186/s12985-023-02001-6

Virology Journal

Table 2 Summary of confidence in effect estimates and ranking of treatments

From: Evaluation of the clinical efficacy of vaginal treatment options for persistent high-risk human papillomavirus infection after excisional treatment of cervical high-grade squamous intraepithelial lesions: a systematic review and Bayesian network meta-analysis

Comparison	Nature of the evidence	Confidence rating	Reason(s) for downgrading
IFN:NT	Mixed	Moderate	Study limitations^a
IFN:BFK	Indirect	Low	Study limitations^a, Imprecision^b
IFN:BSP	Indirect	Low	Study limitations^a, Imprecision^b
IFN:LVC	Indirect	Low	Study limitations^a, Imprecision^b
IFN:PTL	Mixed	Low	Study limitations^a, Inconstantly^c
IFN:FANIFN	Mixed	Moderate	Study limitations^a
IFN:IFNBFK	Mixed	Moderate	Study limitations^a
IFN:IFNLVC	Mixed	Moderate	Study limitations^a
BFK:NT	Mixed	Moderate	Study limitations^a
BFK:BSP	Indirect	Low	Study limitations^a, Imprecision^b
BFK:LVC	Indirect	Low	Study limitations^a, Imprecision^b
BFK:PTL	Indirect	Moderate	Study limitations^a
BFK:FANIFN	Indirect	Moderate	Study limitations^a
BFK:IFNBFK	Mixed	Moderate	Study limitations^a
BFK:IFNLVC	Indirect	Moderate	Study limitations^a
BSP:NT	Mixed	Very low	Study limitations^a, Imprecision^b, Inconstantly^c
BSP:LVC	Indirect	Low	Study limitations^a, Imprecision
BSP:PTL	Indirect	Low	Study limitations^a, Imprecision^b
BSP:FANIFN	Indirect	Low	Study limitations^a, Imprecision^b
BSP:IFNBFK	Indirect	Low	Study limitations^a, Imprecision^b
BSP:IFNLVC	Indirect	Low	Study limitations^a, Imprecision^b
LVC:NT	Mixed	Low	Study limitations^a, Imprecision^b
LVC:PTL	Indirect	Moderate	Study limitations^a
LVC:FANIFN	Indirect	Moderate	Study limitations^a
LVC:IFNBFK	Indirect	Moderate	Study limitations^a
LVC:IFNLVC	Indirect	Moderate	Study limitations^a
PTL:NT	Mixed	Moderate	Study limitations^a
PTL:FANIFN	Indirect	Low	Study limitations^a, Imprecision^b
PTL:IFNBFK	Indirect	Low	Study limitations^a, Imprecision^b
PTL:IFNLVC	Indirect	Low	Study limitations^a, Imprecision^b
FANIFN:NT	Indirect	Moderate	Study limitations^a
FANIFN:IFNBFK	Indirect	Low	Study limitations^a, Imprecision^b
FANIFN:IFNLVC	Indirect	Low	Study limitations^a, Imprecision^b
IFNBFK:NT	Indirect	Moderate	Study limitations^a
IFNBFK:IFNLVC	Mixed	Very low	Study limitations^a, Imprecision^b, Inconstantly^c
IFNLVC:NT	Indirect	Moderate	Study limitations^a
Ranking of treatments		Low	Study limitations^d, Imprecision^e

IFN Interferon, BFK Baofukang, PTL Paiteling, BSP Bletilla striata Sanhuang Powder, LVC Lactobacilli vaginal capsules, FAN + IFN Fuanning + Interferon, IFN + LVC Interferon + Lactobacilli vaginal capsules, IFN + BFK Interferon + Baofukang, NT No treatment
^aDominated by evidence at high or moderate risk of bias
^bConfidence intervals include values favoring either treatment
^cPredictive intervals for treatment effect include effects that would have different interpretations (there is additionally no convincing evidence for the plausibility of the transitivity assumption)
^d51.6% of the information is from studies at moderate or high risk of bias
^eModerate level of imprecision in the analysis

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ISSN: 1743-422X

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