Table 1 Characteristics of Trials Included in the Analysis and Summary Trial Quality Assessment
Source | No of patients | Age of treatment group (Y) | Age of control group (Y) | Cochrane collaboration risk of bias | Follow-up(month) | Type of intervention and dose |
|---|---|---|---|---|---|---|
Yu2021 | 60 | 38.76 ± 5.27 | 37.48 ± 4.92 | Low; unclear; low; low; low; low | 6 | Bletilla striata Sanhuang Powder (Bletilla striata, Coptis chinensis, Cortex phellodendri, Scutellaria baicalensis), 3 g per application, once every other day, for 2 months |
Guan2017 | 80 | 39.61 ± 2.09 | 39.73 ± 2.16 | Unclear; unclear; low; low; low; low | 12 | Baofukang, 1 capsule/d for 2 months |
Meng2015 | 428 | 36.92 ± 2.9 | 37.22 ± 2.2 | Low; unclear; low; low; low; low | 24 | Baofukang, 1 capsule/d for 2 months |
Li2015 | 70 | 36.7 ± 4.5 | 37.1 ± 4.8 | Low; unclear; low; low; low; low | 6 | Interferon, 1 pill/night for 3 months |
WangXL2015 | 112 | 53.67 ± 9.32 | 54.66 ± 9.82 | Low; unclear; low; low; low; low | 12 | Interferon (500,000 IU/pc), once every other day for 3 months |
Feng2019 | 86 | 38.19 ± 6.54 | 38.32 ± 6.43 | Low; unclear; low; low; low; low | 6 | Interferon, once/night, for 3 months |
Cao2011 | 83 | 37.0 ± 3.7 | 38.0 ± 2.4 | Unclear; unclear; low; low; low; low | 12 | Interferon, once every other day for 3 months |
Jia2019 | 120 | 38.12 ± 4.10 | 37.29 ± 4.28 | Low; unclear; low; low; low; low | 6 | Lactobacillus vaginal capsule, 1 capsule/night, 7d for 1 course of treatment, 4 courses of treatment in total |
Han2014 | 96 | Not mentioned | Not mentioned | Unclear; unclear; low; low; low; low | 6 | Interferon (800,000U/capsule), 1 capsule per night for 10d for 3 menstrual cycles |
Cui2013 | 148 | 31.67 ± 6.04 | 32.97 ± 5.57 | Unclear; unclear; low; low; low; low | 12 | Baofukang 1/per night for 3 months |
WangX2015 | 60 | 41.3 ± 3.64 | 40.1 ± 3.51 | Unclear; unclear; low; low; low; low | 6 | Interferon, 1 capsule/d every 2d for 3 months |
Yu2022 | 94 | 44.3 ± 6.2 | 43.9 ± 5.9 | Low; unclear; low; low; low; low | 12 | Interferon, 1 capsule every 2d for 3 months |
Lv2020 | 82 | 37.86 ± 2.43 | 38.13 ± 2.87 | Low; unclear; low; low; low; low | 6 | Baofukang, 1 capsule/d for 2 months |
Cheng2017 | 96 | 45.27 ± 9.13 | 44.89 ± 10.21 | Unclear; unclear; low; low; low; low | 12 | Interferon, 1 g every other day for 3 months |
Zhong2019 | 92 | 40.62 ± 9.23 | 40.37 ± 8.10 | Low; unclear; low; low; low; low | 6 | Baofukang, 1 capsule/d for 14 days |
Zhao2021 | 55 | 36.52 ± 2.18 | 36.19 ± 2.17 | Low; unclear; low; low; low; low | 6 | Interferon, 1 capsule once every other day for 2 months |
Zhan2018 | 126 | 47.1 ± 3.6 | 46.3 ± 3.1 | Unclear; unclear; low; low; low; low | 12 | Interferon, 1 capsule/dose, 1 time/2 days |
Yu2017 | 78 | 43.24 ± 6.17 | 42.69 ± 7.12 | Unclear; unclear; low; low; low; low | 12 | Interferon (100,000 IU/capsule), 1 capsule each time, every other day |
Cui2020 | 180 | 40.99 ± 13.72 | 41.53 ± 13.81 | Low; unclear; low; low; low; low | 6 | Interferon (800,000 U/capsule) 1 capsule each time/night for 3 months |
Zhen2020 | 128 | 36.91 ± 3.22 | 36.84 ± 3.15 | Low; unclear; low; low; low; low | 6 | Interferon, 1 capsule/d, every other day, for 2 months |
Zhang2013 | 113 | 41.2 ± 5.6 | 42.4 ± 4.1 | Unclear; unclear; low; low; low; low | 12 | Interferon (500,000 u/spig), 1 time/2d, 9 times as a course of treatment, 3 courses in total |
Xu2014 | 82 | 42.83 ± 5.42 | 40.65 ± 5.39 | Low; unclear; low; low; low; low | 12 | Interferon, 1 capsule/d, 2 times/d, 10 times/course, 3 courses of continuous treatment |
Jiang2016 | 110 | 41.2 ± 4.7 | 40.7 ± 4.4 | Low; unclear; low; low; low; low | 6 | Interferon, 1 capsule every other day for 3 months, discontinue during menstruation |
Wu2021 | 164 | 37.10 ± 7.69 | 36.98 ± 7.23 | Unclear; unclear; low; low; low; low | 6 | Interferon, 1 capsule/d every other day for 3 months |
Gu2013 | 90 | 39.3 | 40.5 | Unclear; unclear; low; low; low; low | 12 | Interferon, 1 capsule once a night for 1Â month for 10d (stop using during menstruation) for 3Â months |
Liu2019 | 78 | 44.05 ± 7.12 | 43.26 ± 6.89 | Low; unclear; low; low; low; low | 12 | Interferon (5 g/stick), 1 g/2d, continue treatment for 3 months |
Wu2020 | 80 | 42.26 ± 7.89 | 43.78 ± 7.29 | Low; unclear; low; low; low; low | 12 | Interferon, 1 g once every 2 days for 4 months |
Li2014 | 80 | 34.6 ± 6.3 | 34.6 ± 6.3 | Unclear; unclear; low; low; low; low | 6 | Interferon, 1 capsule/2d for 20d/M for 3 months |
Zhu2014 | 144 | 32.5 | 32.5 | Unclear; unclear; low; low; low; low | 6 | Interferon, 1 capsule every other day for 3Â months |
LiRH2015 | 41 | 24–65 | 24–65 | Unclear; unclear; low; low; low; low | 6 | Interferon (0.5 g/stick), 0.1 g/d for 14d |
Ye2017 | 80 | 35.42 ± 6.11 | 35.46 ± 6.03 | Low; unclear; low; low; low; low | 6 | Interferon (100,000 IU/each), 2 capsules/d for 2 months |
Liu2020 | 84 | 35.22 ± 3.34 | 35.08 ± 3.17 | Low; unclear; low; low; low; low | 6 | Interferon, 1 capsule every other day, for 3 weeks |
Pan2017 | 120 | 44.8 ± 5.8 | 44.3 ± 5.4 | Low; unclear; low; low; low; low | 6 | Baofukang, 2 capsules/d, for a course of 16d, two courses in total |
Chang2019 | 100 | 41.51 ± 5.31 | 42.32 ± 5.72 | Low; unclear; low; low; low; low | 6 | Interferon (800,000 U/capsule), 1 capsule/d, for a course of 10d, two courses in total |
He2017 | 116 | 36.79 ± 3.12 | 37.46 ± 3.39 | Low; unclear; low; low; low; low | 6 | Interferon (100,000 IU/capsule), 1 capsule every other day for 2 months |
Zhou2012 | 42 | 36.7 ± 3.2 | 36.7 ± 3.2 | Unclear; unclear; low; low; low; low | 6 | Baofukang, 1 capsule/d for 15d |
Wang2022 | 126 | 33.7 ± 9.0 | 33.6 ± 8.9 | Low; unclear; low; low; low; low | 6 | Interferon, 4 times/d, for 3 months |
Ji2021 | 100 | 33.82 ± 2.31 | 33.65 + 2.28 | Low; unclear; low; low; low; low | 6 | Interferon, every other day for 3 months |
Wang2010 | 148 | 36.5 | 35.7 | Unclear; unclear; low; low; low; low | 12 | Baofukang, 1 per night, for 7Â days |
Ding2015 | 128 | 62.38 ± 8.11 | 63.51 ± 8.65 | Low; unclear; low; low; low; low | 6 | Interferon (500,000 IU/pc), 1 pc every other day for 1 month |
Yao2018 | 80 | 36.4 ± 3.8 | 35.6 ± 5.4 | Unclear; unclear; low; low; low; low | 6 | Paiteling, once every other day, 10 times for one course of treatment, 3 courses in total |
Cao2016 | 60 | 32.6 ± 5.4 | 32.6 ± 5.4 | Unclear; unclear; low; low; low; low | 6 | Baofukang, 1 capsule once/day for 1 month |
Zhao2017 | 96 | 32.7 ± 4.3 | 33.2 ± 5.4 | Unclear; unclear; low; low; low; low | 12 | Interferon (800,000 IU/capsule)for 3 months |
Hao2016 | 113 | 28–50 | 28–50 | Unclear; unclear; low; low; low; high | 6 | Interferon, 1 capsule/d, 10d 1 course, 3 courses in total |
Su2021 | 90 | 37.23 ± 12.60 | 37.22 ± 12.58 | Unclear; unclear; low; low; low; low | 6 | Interferon (800,000 IU/capsule), 10d 1 course, 3 courses in total |
WangCL2015 | 100 | 20–60 | 20–60 | Unclear; unclear; low; low; low; low | 12 | Intervention (100,000 IU/capsule) + FUANNING (the formula consists of 15 g of Radix Sophorae Favescentis, 15 g of Phellodendron Chinense, 15 g of Fructus Cnidii, 10 g of Cyrtomium Fortunei, 10 g of Radix Clematis, 10 g of Rhizoma, 30 g of fructus Carpesii Abrotanoidis, 3 g of Peppermint, 3 g of Borneol), once every other day for 3 months Interferon (100,000 IU/capsule), 1 capsule/d, once every other day for 3 months |
Peng2021 | 90 | 39.61 ± 4.28 | 39.24 ± 4.09 | Unclear; unclear; low; low; low; low | 6 | 1. Interferon (100,000 IU), 1 capsule/d, once every other day for 3 months 2. Lactobacilli vaginal capsules (0.25 g), 1 capsule/d + Interferon (100,000 IU), 1 capsule/d, once every other day for 3 months 3. Interferon (100,000 IU) + Baofukang, 1 capsule/d for 3 months |
Zhou2021 | 60 | 40.18 ± 5.13 | 40.26 ± 5.01 | Low; unclear; low; low; low; low | 6 | 1. Lactobacilli vaginal capsules (0.25 g/capsule) + Interferon (100,000 IU), 1 capsule/dose, 1 time every 2 days, 10 capsules for 1 course of treatment, total 3 courses of treatment 2. Lactobacillus vaginal capsules (0.25 g/capsule), 1 capsule/dose, 1 time every 2 days, 10 capsules for 1 course of treatment, total 3 courses of treatment |
Chen2017 | 100 | 43.17 ± 6.93 | 44.05 ± 6.95 | Low; unclear; low; low; low; low | 24 | 1. Baofukang, 2 capsules/d for 16d per month for 3 months 2. Baofukang, 2 capsules/d for 16d per month + Interferon (100,000 IU), 1/d, for 3 months |
Zhong2021 | 187 | 45.56 ± 5.15 | 46.21 ± 4.76 | Low; unclear; low; low; low; low | 12 | 1. Baofukang, 2 capsules/d for 3 months 2. Baofukang, 2 capsules/d + Interferon (10 g/pc), 1 g once every other day, 6 to 10 times as a course of treatment, 3 months in total |
Huang2017 | 84 | 38.2 ± 4.1 | 37.9 ± 4.2 | Low; unclear; low; low; low; low | 6 | 1. Lactobacilli vaginal capsules (0.25 g/capsule), 1 capsules/d + Interferon (100,000 IU), 1 capsule once every other day for 3 months 2. Interferon (100,000 IU), 1 capsule once every other day for 3 months |
Zhao2019 | 100 | 31.76 ± 3.47 | 32.17 ± 3.16 | Unclear; unclear; low; low; low; low | 12 | 1. Interferon, 1 capsule once every other day for 6 weeks 2. Paiteling, with continuous medication for 3 d and discontinued for 4 d for 6 weeks |