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Fig. 3 | Virology Journal

Fig. 3

From: Intragenomic rearrangements involving 5′-untranslated region segments in SARS-CoV-2, other betacoronaviruses, and alphacoronaviruses

Fig. 3

A. Insertion of 5′-UTR segment into the nucleotide segment encoding the serine-arginine-rich region of the nucleocapsid (N) in SARS-CoV-2. The R203K and G204R amino acid substitutions (blue arrows) which are commonly present concomitantly are encoded in this case by the insertion of a 5′-TR segment into the serine-arginine (SR)-rich region of the N protein at the end of a strong immunodominant B-cell epitope (purple box; [105]). Examples of isolates (a. and b.) with 5′-UTR sequences are provided in the figure and a full listing is provided in the Additional file 1: legend to Fig. S3. B. Secondary structures of N and Nx RNAs. Color scheme is as in preceding figures

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Virology Journal

ISSN: 1743-422X