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Fig. 2 | Virology Journal

Fig. 2

From: Mutagenesis of the di-leucine motif in the cytoplasmic tail of newcastle disease virus fusion protein modulates the viral fusion ability and pathogenesis

Fig. 2

Pathogenicity of rSG10* and rSG10*-F/L537A mutants in 3-week-old SPF chickens. A Clinical symptom score of chickens infected with rSG10* or rSG10*-F/L537A (0, healthy; 1, sick; 2, wing drop/paralysis/torticollis/incoordination; 3, prostration; 4, dead); n = 10. B Survival curve of 3-week-old SPF chickens inoculated with rSG10* or rSG10*-F/L537A; n = 10. C Gross lesions of chickens infected with PBS, rSG10*, or rSG10*-F/L537A at 5 dpi. D Histopathology changes in the chickens in each group at 5 dpi. E Replication ability of rSG10* and rSG10*-F/L537A in vivo. Three infected chickens in each group were euthanized at 3, 5, and 7 dpi, and indicated tissues were collected to detect the viral loads by RT-qPCR

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Virology Journal

ISSN: 1743-422X