Analysis of 3.5 million SARS-CoV-2 sequences reveals unique mutational trends with consistent nucleotide and codon frequencies

Table 1 Sequence Counts by Month and Clade

Month	Alpha	Beta/Mu	Gamma/Lambda	Delta	Omicron	Month Total
19-Dec	2	9	5	2	5	23
20-Jan	77	162	111	33	53	436
20-Feb	56	246	210	71	77	660
20-Mar	155	9526	4705	178	260	14,824
20-Apr	52	8377	*7797*	58	54	16,338
20-May	17	*5085*	*4748*	28	12	9890
20-Jun	16	*5075*	*7371*	7	16	12,485
20-Jul	7	*6362*	*12,014*	5	9	18,397
20-Aug	6	*5480*	*11,240*	16	12	16,754
20-Sep	16	*6824*	*8140*	20	16	15,016
20-Oct	65	*8703*	*8449*	20	4	17,241
20-Nov	1426	*14,171*	*10,442*	6	–	26,045
20-Dec	*10,903*	*21,645*	*12,549*	27	15	45,139
21-Jan	*36,946*	*30,750*	*18,350*	117	32	86,195
21-Feb	*64,847*	*24,422*	*15,173*	93	18	104,553
21-Mar	*130,982*	*24,750*	*23,150*	597	14	179,493
21-Apr	*132,923*	*18,068*	*32,294*	2810	27	186,122
21-May	*91,528*	*8342*	*33,667*	*17,588*	18	151,143
21-Jun	23,524	3881	*24,279*	*47,694*	50	99,428
21-Jul	2955	2747	*19,767*	*170,492*	44	196,005
21-Aug	363	1074	*8543*	*303,252*	16	313,248
21-Sep	36	631	1187	*239,152*	9	241,015
21-Oct	11	397	220	*197,488*	7	198,123
21-Nov	6	510	147	*248,064*	296	249,023
21-Dec	14	480	143	*166,615*	*63,644*	230,896
22-Jan	2	32	20	*12,964*	*291,817*	304,835
22-Feb	3	5	11	550	*253,746*	254,315
22-Mar	–	2	2	98	*233,137*	233,239
22-Apr	–	2	1	25	*132,539*	132,567
22-May	–	–	6	5	*133,097*	133,108
22-Jun	–	–	–	8	*85,050*	85,058
22-Jul	–	–	–	–	1877	1877
Clade Total	496,938	207,758	264,741	1,408,083	1,195,971	3,573,491

The numbers in bold italic represent those months which both (1) are after the date that the clade was first noted by the WHO and (2) contain over 5,000 sequences

ISSN: 1743-422X