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Table 3 The treatments and outcomes of patients

From: SARS-CoV-2 BA.2 (Omicron) variant infection in pediatric liver transplanted recipients and cohabitants during 2022 Shanghai outbreak: a prospective cohort

  

Case A

Case B

Case C

Case D

Case E

Treatment for COVID‐19

Antipyretic

None

Ibuprofen

Ibuprofen

Ibuprofen

None

Antibiotic

None

Meropenem

Cefdinir

Meropenem

Cefixime → Cefoperazone and Sulbactam

Immunosuppression treatment

Pre-COVID‐19

CsA 80 mg bid + PA 7.5 mg qd + MMF 0.5 g bid

CsA 40 mg bid + MMF 0.25 mg qd

TAC 2.5 mg bid

TAC 2.5 mg bid

CsA 0.15 mg

During COVID‐19

Extenuate MMF first, then PA, finally to CsA 45 mg bid

CsA 30 mg bid

Extenuate TAC three times to 1.0 mg-1.5 mg

Stop all the immunosuppressant

Stop all the immunosuppressant

At discharge

CsA 45 mg bid

CsA 30 mg bid + MMF 0.25 mg qd

TAC 1.0 mg-1.5 mg bid

TAC 2.5 mg bid

none

At the latest follow-up

CsA 60 mg bid

CsA 30 mg bid

TAC 2.0 mg-1.5 mg

TAC 2.5 mg bid

CsA 0.15 mg

Hospitalization

Times

2

1

1

1

1

Total duration (day)

46

0

21

27

19

COVID-19 outcome

 

Cured

Cured

Cured

Cured

 Cured

Follow‐up duration after the diagnosis of SARS-CoV-2 infection (day)

 

213

228

203

140

 167

COVID-19 sequelae or reinfection

 

None

None

None

None

 None

Blood test at the latest follow-up

WBC3.5–9.5 × 10^9/L

11.77↑

8.9

2.4

10.91

9.73

Lymphocytes (#)1.2–3.4 × 10^9/L

4.29↑

3.52↑

25.1

1.64

4.16↑

CRP0-8 mg/L

 < 0.5

 < 0.5

 < 0.5

 < 0.5

 < 0.5

ALT9-50 IU/L

31

46

24

16

40

AST15-40 U/L

44↑

64

22

38

67

γ-GT10-60 U/L

42

16

19

9

16

Newly-onset LT complication

 

None

None

None

None

None

  1. COVID-19 Corona Virus Disease 2019, SARS‐CoV‐2 Severe Acute Respiratory Syndrome Coronavirus 2, TAC – tacrolimus, PA prednisone acetate, MMF mycophenolate mofetil, CsA cyclosporin A, WBC white white blood cell, CRP C‐reactive protein, ALT alanine transaminase, AST aspartate transaminase, γ-GT gamma‐glutamyl transferase