Fig. 4

Spaghetti plot with serial neutralizing antibody (NAb) measurements and the corresponding linear mixed-effects (LME) model predictions. NAb titer measurements from the predefined sampling time points at day 0, 30, 90 and 180 after hospital admission were used. The mean days since symptom onset at admission was seven days and is added to the sampling time points in the figures to describe NAb titers in relation to symptom onset. All titers are presented in log₂ scale. A Spaghetti plot showing all serial NAb titer measurements from the predefined sampling time points. Samples from the same patients are marked with connecting black lines. Dots and triangles represent NAb measurement at a specific time point. Vaccination prior to sample collection is marked in blue, while samples from non-vaccinated patients are marked in red. Patients with high disease severity are marked with a triangle, while patients with low disease severity are marked with a dot. B LME model predictions with model predictions stratified by disease severity. Samples from vaccinated patients on day 187 were excluded from the model. Standard error is plotted as error bars