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Fig. 1 | Virology Journal

Fig. 1

From: Exaggerated levels of some specific TLRs, cytokines and chemokines in Japanese encephalitis infected BV2 and neuro 2A cell lines associated with worst outcome

Fig. 1

A–C Virus propagation in mice brain: Mice were inoculated intracerebral (IC) with GP-78 strain of Japanese encephalitis virus (A) Hunching of the back (indicated by arrow), and slight hind limb disability was observed on 5 dpi. B, C The typical symptoms of encephalitis characterized by total hind limb paralysis (indicated by arrow), tremors, and convulsions with altered consciousness became evident on 6 and 7 dpi. The mice were almost moribund when they were sacrificed. D Balb/c mice were infected with JEV. PBS inoculated mice were used as mock control. Body weight of mice from both the groups was measured at different day post infection. The drop in body weight of JEV-infected mice was noticed compared to mock controls. E Six well tissue culture plates demonstrating the virus titration from the brain of intracerebrally inoculated mice. F Blood brain barrier damage of mice infected with JEV (IC challenge) by Evan’s blue dye exclusion test

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Virology Journal

ISSN: 1743-422X