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Fig. 4 | Virology Journal

Fig. 4

From: Single-dose rAAV5-based vaccine provides long-term protective immunity against SARS-CoV-2 and its variants

Fig. 4

Durable immune responses and broad protection against SARS-COV-2 induced by the ssAAV5-RBD-plus vaccine in mice over one-year post-inoculation. ssAAV5-RBD-plus induced high levels of RBD-specific IgG (A), and prolonged and potent humoral responses, including IgM (B), IgG1 (C), IgG2a (D), IgG2b (E) and IgG3 (F); Secretion of IFN-γ (G) and IL-4 (H) from CD4+ was significantly upregulated. Values represent mean ± SEM; significant difference versus control group, **P < 0.01, ***P < 0.001.

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Virology Journal

ISSN: 1743-422X