Fig. 1

Translesion synthesis gene expression is frequently elevated in cervical cancers compared to other cancer types. A Overall frequency with which at least tumors have elevated (z > 2) expression of at least one TLS gene (left). The frequency with which tumors have elevated (z > 2) expression of individual TLS genes (right). Unbiased cluster analysis was used to group individual TLS genes by similarities of gene expression changes. B Gene ontology analysis of cervical cancers (CaCx) and cell lines with elevated E2F1 expression (Increased E2F1) showing enrichment of genes involved in the indicated cellular processes. The size of the circle indicates the relative breadth of the cellular process, with large circles indicating broad categories and smaller circles indicating more specific cellular responses. p-values are indicated by the color of the circle with darker greens denoting lower p-values than lighter colored circles. C This table shows (i) the extent that expression of individual TLS genes correlates with E2F1 expression, (ii) the nature of that correlation, and (iii) how the expression of TLS genes changes with cervical cancer progression. “ − “ indicates that a correlation does not exist or did not reach statistical significance. “ + ”,” +  + ”,” +  +  + ” indicate increasing magnitudes of correlation with E2F1 expression. “POS” indicates the correlation between the expression of the indicated TLS gene and E2F1 is positive. “NEG” indicates the correlation is negative. “Up” indicates that expression of the indicated TLS gene increases as cervical cancers progress from early to later stages of the disease. “Neutral” indicates that these changes are inconsistent (both up and down). “N/A” indicates that this gene was not included in the analyzed data set. “Down” indicates that expression of the indicated gene decreased with disease progression