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Table 1 Principal demographics, clinical characteristics, and CMV serology of the patient group

From: Cytomegalovirus infection may be oncoprotective against neoplasms of B-lymphocyte lineage: single-institution experience and survey of global evidence

 

IgG positive

IgG negative

p-value

Patients (N = 83)

75 (90.4%)

8 (9.6%)

N/A

Age (median, years)

50.05

43.75

0.070a

Age categories (years)

20–39

18 (85.7%)

3 (14.3%)

0.054b

40–59

34 (89.5%)

4 (10.5%)

 

 > 59

23 (95.8%)

1 (4.2%)

 

Gender

Male

37 (86%)

6 (14%)

0.266c

Female

38 (95%)

2 (5%)

 

Diagnose; ICD-O-3 code*

   

Non-Hodgkin lymphoma; 9591/3

33 (94.3%)

2 (5.7%)

0.339c

Hodgkin’s disease; 9650/3

18 (81.8%)

4 (18.2%)

 

B-chronic lymphocytic leukemia; 9823/3

9 (90%)

1 (10%)

 

Waldenström macroglobulinemia; 9761/3

2 (100%)

0

 

B-cell lymphoma, NOS; 9690/3

2 (100%)

0

 

Plasma cell myeloma; 9732/3

2 (66.7%)

1 (33.7%)

 

Hairy cell leukemia; 9940/3

2 (100%)

0

 

B-cell acute lymphoblastic leukemia; 9811/3

7 (100%)

0

 

Antiviral therapy (Acyclovir)**

   

Yes

17 (81%)

4 (19%)

0.438c

No

36 (89.5%)

4 (10.5)

 

Chemotherapy

   

Yes

38 (92.7%)

3 (7.3%)

0.706c

No

25 (83.3%)

5 (16.7%)

 
  1. *Diagnostic recognition and technical signification of lymphoid B-cell dyscrasias listed were morphologically code-specified and comply with criteria of the Classification of Diseases for Oncology (World Health Organization) and the 2016 revision of lymphoid neoplasms [35, 69]
  2. **Data missing in 22 patients
  3. Data missing in 12 patients
  4. aMann–Whitney U test
  5. bMantel–Haenszel chi square test for trend
  6. cFisher's Exact Test