Fig. 5

Schematic representation of the Wnt canonical pathway. The Wnt canonical pathway is activated after WNT ligand binding to receptors complex Frizzled-LRP5/6. This interaction allows the formation of a complex, the “signalosome”, that blocked β-catenin degradation leading to its accumulation in cytosol and translocation in nucleus. The β-catenin forms a transcription complex with the transcription factor TCF and LEF to activate genes expression. On the OFF state, β-catenin is continually degraded by the destruction complex which promotes β-catenin phosphorylation leading to its degradation by the proteasome. Some interesting genes identified in Table 2 are reported with arrows (red color for upregulated genes and green for downregulated genes)