Seroconversion following the first, second, and third dose of SARS-CoV-2 vaccines in immunocompromised population: a systematic review and meta-analysis

Mehrabi Nejad, Mohammad-Mehdi; Shobeiri, Parnian; Dehghanbanadaki, Hojat; Tabary, Mohammadreza; Aryannejad, Armin; Haji Ghadery, Abdolkarim; Shabani, Mahya; Moosaie, Fatemeh; SeyedAlinaghi, SeyedAhmad; Rezaei, Nima

doi:10.1186/s12985-022-01858-3

Virology Journal

Table 2 Results of between-group meta-analyses

From: Seroconversion following the first, second, and third dose of SARS-CoV-2 vaccines in immunocompromised population: a systematic review and meta-analysis

Vaccination dose	Sub-group	Comparison	No. studies	No. observations	No. events	Meta-analysis			Heterogeneity
Vaccination dose	Sub-group	Comparison	No. studies	No. observations	No. events	Effect size (%)	95% Confidence interval (%)	P value	I² (%)	P value
First dose	Overall		45	7460	1979	26.17	19.01, 33.99	–	97.1	< 0.0001
	Type of vaccine	mRNA	35	4894	1147	24.02	15.87, 33.2	0.0392	97.1	–
		mRNA or vector	4	1107	469	30.88	18.27, 44.53		92.9
		Vector	5	549	193	44.59	16.8, 74.26		90.8
		Inactivated	1	910	170	18.68	16.21, 21.28		–
	Type of vaccine pair-wised	mRNA versus vector	39	5443	1340	25.89	17.82, 34.85	0.1790	97	< 0.0001
	Etiology	Malignancy	13	1465	498	37.05	23.19, 52.05	0.0226	96.4	–
		Transplant	23	3265	507	17.01	9.44, 26.15		94.8
		Autoimmune	9	2730	974	36.4	20.35, 54.15		97.7
	Etiology pair-wised	Malignancy versus autoimmune	22	4195	1472	36.76	26.3, 47.88	0.9514	96.9	< 0.0001
		Malignancy versus transplant	36	4730	1005	23.73	16.07, 32.32	0.0171	96.3	< 0.0001
		Autoimmune versus transplant	32	5995	1481	22.07	14.34, 30.88	0.0404	97.3	< 0.0001
Second dose	Overall		70	13181	8326	57.11	49.22, 64.83	–	98.4	< 0.0001
	Type of vaccine	mRNA	63	10441	6651	56.41	48.01, 64.64	< 0.0001	98.1	–
		mRNA or vector	2	908	777	82.83	58.24, 97.77		98.3
		Vector	2	771	134	19.12	11.27, 28.37		49.7
		Inactivated	3	1061	764	75.8	58.81, 89.46		91.3
	Type of vaccine pair-wised	mRNA versus vector	65	11212	6785	55.28	46.98, 63.44	< 0.0001	98.4	< 0.0001
	Etiology	Malignancy	18	2879	2076	72.15	59.24, 83.45	< 0.0001	97.6	–
		Transplant	36	5836	2493	38.29	29.93, 46.99		96.2
		Autoimmune	15	4440	3737	80.25	68.08, 90.14		96.7
	Etiology pair-wised	Malignancy versus autoimmune	33	7319	5815	75.9	67.07, 83.76	0.3471	97.5	< 0.0001
		Malignancy versus transplant	54	8715	4571	49.93	41.36, 58.51	< 0.0001	97.8	< 0.0001
		Autoimmune versus transplant	51	10276	6230	51.21	41.94, 60.44	< 0.0001	98.6	< 0.0001
Third dose	Overall		7	909	505	48.65	36.43, 62.79	–	94.4	< 0.0001

mRNA, messenger ribonucleic acid

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ISSN: 1743-422X

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